In the mathematical subject of topology, an ambient isotopy, also called an h-isotopy, is a kind of continuous distortion of an ambient space, for example a manifold, taking a submanifold to another submanifold.

In the mathematical subject of knot theory, regular isotopy is the equivalence relation of link diagrams that is generated by using the 2nd and 3rd Reidemeister moves only.

In mathematics, especially in differential topology, Thom's second isotopy lemma is a family version of Thom's first isotopy lemma; i.e., it states a family of maps between Whitney stratified spaces is locally trivial when it is a Thom mapping.