The (also simply called Black Mesa) a fictional underground laboratory complex that serves as the primary setting for the video game Half-Life and its expansions, as well as its unofficial remake, Black Mesa.

an Oklahoma state park in Cimarron County, near the western border of the Oklahoma panhandle and New Mexico.

The Black Mesa and Lake Powell Railroad was an electrified private railroad operating in Northern Arizona, USA within the Navajo Nation which transported coal from the Peabody Energy Kayenta Mine near Kayenta, Arizona to the Navajo Generating Station power plant at Page, Arizona.