Benediction of the Blessed Sacrament, also called Benediction with the Blessed Sacrament or the Rite of Eucharistic Exposition and Benediction, is a devotional ceremony, celebrated especially in the Roman Catholic Church, but also in some other Christian traditions such as Anglo-Catholicism, whereby a bishop, a priest, or a deacon blesses the congregation with the Eucharist at the end of a period of adoration.

The hand of benediction, also known as benediction sign or preacher's hand, has been said to occur as a result of prolonged compression or injury of the median nerve at the forearm or elbow.