The Assistant to the Secretary of Defense for Public Affairs, or ATSD, is the principal staff advisor and assistant to the Secretary of Defense and Deputy Secretary of Defense for public information, internal information, community relations, information training, and audiovisual matters in support of Department of Defense activities, leading a worldwide public affairs community of some 3,800 military and civilian personnel.

The assistant secretary for health is a senior U.S. government official within the United States Department of Health and Human Services.

Assistant Secretary of the Navy is the title given to certain civilian senior officials in the United States Department of the Navy.

Assistant Secretary of State is a title used for many executive positions in the United States Department of State, ranking below the under secretaries.