(July 5, 1811 – April 22, 1888) an American pioneer who led a large group of settlers along the Oregon Trail to the Oregon Country.

(born November 25, 1971) an American actress.

Katherine Alice Applegate (born October 9, 1956), known professionally as K. A. Applegate, is an American young adult and children's fiction writer, best known as the author of the Animorphs, Remnants, and Everworld book series.

Royce Dwayne Applegate (December 25, 1939 – January 1, 2003) was an American actor and screenwriter who was first billed as Roy Applegate.

Jodi Applegate (born May 2, 1964)"Anchor Jodi Applegate Shares a Secret" nypost.com. is an American broadcast journalist.

Jessica-Jane Applegate MBE (born 22 August 1996) is a British Paralympic swimmer.

(June 21, 1914 – July 14, 1998) an American military officer who worked for the Office of Strategic Services, where he trained Allied special forces personnel in close-quarters combat during World War II.

an emigrant trail through the present-day U.S. states of Idaho, Nevada, California, and Oregon used in the mid-19th century by emigrants on the American frontier.

Frederick Daniel Applegate (November 9, 1917 – January 17, 1999) was director of product engineering for Convair, a McDonnell Douglas subcontractor supplying parts for the company's newest aircraft, the DC-10 trijet, during the early 1970s.