The term “irritable” has been used in literature as a multifaceted descriptor that captures both emotional turbulence and physical discomfort. In many works by Fyodor Dostoyevsky, for example, the word underscores characters’ internal conflicts and precarious mental states, revealing deep-seated unease and susceptibility to offense [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]. Authors like Chekhov and Dickens similarly employ “irritable” to denote a character’s quick temper or petulance in everyday interactions, often highlighting a broader commentary on human frailty amidst societal pressures [15], [16], [17], [18], [19], [20], [21], [22]. Meanwhile, writers such as Edgar Allan Poe and H. G. Wells use the term to portray a moodiness that sometimes borders on physical exhaustion or illness, reinforcing the idea that irritability can be both a mental and corporeal state [23], [24], [25], [26]. Overall, “irritable” serves as a versatile marker in literature, vividly illustrating the delicate interplay between emotional, psychological, and physical realms.