Sorry, no online dictionaries contain the exact phrase mainly responsible.
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Reverse dictionary results:
1. give
2. have
3. stand
4. throw
5. carry
6. testosterone
7. reply
8. trust
9. trusted
10. clay
11. division
12. dna
13. afrikaans
14. air
15. airs
16. alchemy
17. analysis
18. asphalt
19. bachelor
20. back
21. bookish
22. bulimia
23. buy
24. catfish
25. come
26. coot
27. crude
28. desert
29. dive
30. education
31. especially
32. extrovert
33. fatigue
34. final
35. flesh
36. foremost
37. freighter
38. galena
39. get
40. grassland

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You can look up the words in the phrase individually using these links:   mainly ?   responsible ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
main*to search for words beginning with main, or
*ibleto search for words ending with ible
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