Usually means: Full of youthful, aggressive energy.
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We found 5 dictionaries that define the word piss and vinegar:

General (4 matching dictionaries)
  1. piss and vinegar: Merriam-Webster
  2. piss and vinegar: Oxford Learner's Dictionaries
  3. piss and vinegar: Wiktionary
  4. piss and vinegar: Dictionary.com

Slang (1 matching dictionary)
  1. piss and vinegar: Urban Dictionary

Definitions from Wiktionary (piss and vinegar)

noun:  (US, slang, vulgar) Exuberance or enthusiasm, especially to an excessive degree; bravado; youthful energy.

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