Usually means: Respectful form of address, gentlemen.
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We found 21 dictionaries that define the word sirs:

General (11 matching dictionaries)
  1. sirs: Merriam-Webster
  2. sirs: Collins English Dictionary
  3. Sirs, sirs: Vocabulary.com
  4. Sir's, Sirs, sirs: Wordnik
  5. sirs: Cambridge Advanced Learner's Dictionary
  6. Sirs, sirs: Wiktionary
  7. SIRS, Sirs: Dictionary.com
  8. sirs: Cambridge Essential American English Dictionary
  9. SIRS (disambiguation), SIRS, Sirs: Wikipedia, the Free Encyclopedia
  10. SIRS: Dictionary of Americanisms (1848)
  11. SIRS: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. SIRS: Encyclopedia

Medicine (3 matching dictionaries)
  1. SIRS: Merriam-Webster Medical Dictionary
  2. SIRS: Dictionary of Cancer Terms
  3. SIRS: Medical dictionary

Miscellaneous (2 matching dictionaries)
  1. SIRS: Acronym Finder
  2. AbbreviationZ (No longer online)

Science (1 matching dictionary)
  1. SIRS: Cytokines & Cells Online Pathfinder Encyclopaedia

Slang (1 matching dictionary)
  1. SIRS: Urban Dictionary

Tech (2 matching dictionaries)
  1. SIRS: GEOGRAPHIC INFORMATION SYSTEMS, CARTOGRAPHY, AND REMOTE SENSING
  2. Glossary of Meteorology (No longer online)

(Note: See sir as well.)

Definitions from Wiktionary (SIRS)

noun:  Abbreviation of systemic inflammatory response syndrome.

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