Usually means: Expression of discomfort or surprise.
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We found 22 dictionaries that define the word oof:

General (10 matching dictionaries)
  1. oof: Longman Dictionary of Contemporary English
  2. oof: Merriam-Webster
  3. oof, oof: Oxford Learner's Dictionaries
  4. oof: Collins English Dictionary
  5. Oof, oof: Wordnik
  6. oof: Wiktionary
  7. OOF: Dictionary.com
  8. Oof (album), Oof: Wikipedia, the Free Encyclopedia
  9. OOF: Stammtisch Beau Fleuve Acronyms
  10. oof: TheFreeDictionary.com

Computing (4 matching dictionaries)
  1. OOF: Free On-line Dictionary of Computing
  2. OOF: Netlingo
  3. SMS Dictionary (No longer online)
  4. OOF: Encyclopedia

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Miscellaneous (5 matching dictionaries)
  1. Ka-BOOM! Comicbook Words on Historical Principles (No longer online)
  2. CIA World Factbook (No longer online)
  3. OOF: Acronym Finder
  4. OOF: Three Letter Words with definitions
  5. AbbreviationZ (No longer online)

Slang (2 matching dictionaries)
  1. oof: Green’s Dictionary of Slang
  2. O.O.F, OOF: Urban Dictionary

Definitions from Wiktionary (oof)

noun:  A sound made in pain, as when expelling air after being struck.
noun:  (Internet) Something cringeworthy, or which arouses disappointment, often used in conjunction with the qualifier big.
noun:  (UK, slang, dated) Money.

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