Usually means: Laughing out loud in French.
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We found 18 dictionaries that define the word mdr:

General (8 matching dictionaries)
  1. MDR: Collins English Dictionary
  2. mdr: Wordnik
  3. MDR: Wiktionary
  4. MDR: Infoplease Dictionary
  5. MDR: Dictionary.com
  6. MDR, Mdr: Wikipedia, the Free Encyclopedia
  7. MdR: Stammtisch Beau Fleuve Acronyms
  8. MDR: TheFreeDictionary.com

Computing (2 matching dictionaries)
  1. Technology Terms and Acronyms (No longer online)
  2. BABEL: Computer Oriented Abbreviations and Acronyms (No longer online)

Medicine (4 matching dictionaries)
  1. MDR: Merriam-Webster Medical Dictionary
  2. MDR: MedTerms.com Medical Dictionary
  3. MDR: Medical dictionary
  4. MDR: Drug Medical Dictionary

Miscellaneous (2 matching dictionaries)
  1. mdr: Acronym Finder
  2. AbbreviationZ (No longer online)

Tech (2 matching dictionaries)
  1. MDR: GEOGRAPHIC INFORMATION SYSTEMS, CARTOGRAPHY, AND REMOTE SENSING
  2. DOD Dictionary of Military Terms: Joint Acronyms and Abbreviations (No longer online)

Definitions from Wiktionary (MDR)

adjective:  (pathology) Initialism of multi-drug resistant. (used to refer to strains of tuberculosis).
noun:  (law) Initialism of mandatory declassification review.

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