Usually means: Most intelligent, clever, or knowledgeable.
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We found 11 dictionaries that define the word brainiest:

General (11 matching dictionaries)
  1. brainiest: Merriam-Webster
  2. brainiest: Oxford Learner's Dictionaries
  3. brainiest: Collins English Dictionary
  4. brainiest: Vocabulary.com
  5. Brainiest, brainiest: Wordnik
  6. brainiest: Cambridge Advanced Learner's Dictionary
  7. brainiest: Wiktionary
  8. brainiest: Dictionary.com
  9. brainiest: Cambridge Essential American English Dictionary
  10. Brainiest: Wikipedia, the Free Encyclopedia
  11. brainiest: TheFreeDictionary.com

(Note: See brainy as well.)

Definitions from Wiktionary (brainy)

adjective:  (informal) Very intellectually capable.
adjective:  (rare) Of or relating to the brain.
▸ Also see brainy


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