Usually means: Hallucinogenic snuff from Anadenanthera seeds.
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We found 3 dictionaries that define the word yopo:

General (2 matching dictionaries)
  1. yopo: Wiktionary
  2. Yopo: Wikipedia, the Free Encyclopedia

Slang (1 matching dictionary)
  1. yopo: Urban Dictionary

Definitions from Wiktionary (yopo)

noun:  A perennial South American tree, Anadenanthera peregrina, that has a number of traditional uses.

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