Usually means: Stimulants that increase energy, alertness.
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We found 22 dictionaries that define the word uppers:

General (13 matching dictionaries)
  1. uppers: Longman Dictionary of Contemporary English
  2. uppers: Merriam-Webster
  3. uppers: Oxford Learner's Dictionaries
  4. uppers: Collins English Dictionary
  5. uppers: Vocabulary.com
  6. Uppers, uppers: Wordnik
  7. uppers: Cambridge Advanced Learner's Dictionary
  8. uppers: Wiktionary
  9. uppers: Dictionary.com
  10. uppers: Cambridge Essential American English Dictionary
  11. Uppers: Wikipedia, the Free Encyclopedia
  12. Uppers: The Word Detective
  13. uppers: TheFreeDictionary.com

Business (1 matching dictionary)
  1. uppers: Legal dictionary

Computing (1 matching dictionary)
  1. uppers: Encyclopedia

Medicine (2 matching dictionaries)
  1. uppers: Merriam-Webster Medical Dictionary
  2. uppers: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. uppers: Idioms

Slang (3 matching dictionaries)
  1. Uppers: Street Terms: Drugs and the Drug Trade
  2. uppers: Urban Dictionary
  3. Uppers: Twists, Slugs and Roscoes: Hardboiled Slang

Sports (1 matching dictionary)
  1. Uppers: Skydiving Glossary

(Note: See upper as well.)

Definitions from Wiktionary (uppers)

noun:  The parts of a pair of shoes that do not normally contact the ground.

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