Usually means: Extra chromosome causes Down syndrome.
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We found 19 dictionaries that define the word trisomy 21:

General (10 matching dictionaries)
  1. trisomy 21: Merriam-Webster
  2. trisomy-21: Oxford Learner's Dictionaries
  3. trisomy 21: American Heritage Dictionary of the English Language
  4. trisomy 21: Vocabulary.com
  5. trisomy 21: Wiktionary
  6. trisomy 21: Dictionary.com
  7. Trisomy 21: Rhymezone
  8. trisomy-21, trisomy 21: FreeDictionary.org
  9. trisomy 21: Mnemonic Dictionary
  10. trisomy 21: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. Trisomy-21, trisomy 21: Encyclopedia

Medicine (7 matching dictionaries)
  1. trisomy 21: Merriam-Webster Medical Dictionary
  2. Trisomy 21, Trisomy 21: Merck Manuals
  3. online medical dictionary (No longer online)
  4. Health and Wellness Dictionary (No longer online)
  5. Specific Diseases/Disorders (No longer online)
  6. Trisomy-21, trisomy 21: Medical dictionary
  7. University of Maryland Glossary of Medical Terms (No longer online)

Slang (1 matching dictionary)
  1. trisomy 21: Urban Dictionary

Definitions from Wiktionary (trisomy 21)

noun:  The presence of three copies of the 21st chromosome in the karyotype.

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