Usually means: Holistic analysis of biological interactions.
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We found 7 dictionaries that define the word systems biology:

General (2 matching dictionaries)
  1. systems biology: Wiktionary
  2. Systems Biology, Systems biology: Wikipedia, the Free Encyclopedia

Medicine (3 matching dictionaries)
  1. Systems biology: MedTerms.com Medical Dictionary
  2. Medical Dictionary (No longer online)
  3. Systems biology: Drug Medical Dictionary

Science (2 matching dictionaries)
  1. Drug Discovery and Development (No longer online)
  2. systems biology: PlanetMath Encyclopedia

Definitions from Wiktionary (systems biology)

noun:  (biology) The systematic study of the complex interactions in biological systems, with integral help from computational and mathematical analysis and modeling.
noun:  (by extension) The study of the self-organizing behaviour of complex, dynamic non-biological systems.

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