Usually means: Left-handed, especially in sports.
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We found 28 dictionaries that define the word southpaw:

General (23 matching dictionaries)
  1. southpaw: Longman Dictionary of Contemporary English
  2. southpaw: Merriam-Webster
  3. southpaw: Oxford Learner's Dictionaries
  4. southpaw: American Heritage Dictionary of the English Language
  5. southpaw: Collins English Dictionary
  6. southpaw: Vocabulary.com
  7. Southpaw, southpaw: Wordnik
  8. southpaw: Cambridge Advanced Learner's Dictionary
  9. southpaw: Wiktionary
  10. southpaw: Webster's New World College Dictionary, 4th Ed.
  11. southpaw: The Wordsmyth English Dictionary-Thesaurus
  12. southpaw: Infoplease Dictionary
  13. southpaw: Dictionary.com
  14. southpaw: Online Etymology Dictionary
  15. southpaw: Cambridge Essential American English Dictionary
  16. Southpaw (Gilbert O'Sullivan album), Southpaw (Pink Lady song), Southpaw (album), Southpaw (boxing), Southpaw (comics), Southpaw (disambiguation), Southpaw (film), Southpaw (mascot), Southpaw (soundtrack), Southpaw, The Southpaw: Wikipedia, the Free Encyclopedia
  17. southpaw: Rhymezone
  18. southpaw: FreeDictionary.org
  19. southpaw: Mnemonic Dictionary
  20. Southpaw: The Word Detective
  21. southpaw: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. southpaw: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. southpaw: A Word A Day

Slang (2 matching dictionaries)
  1. southpaw, southpaw: Green’s Dictionary of Slang
  2. southpaw: Urban Dictionary

Sports (1 matching dictionary)
  1. Southpaw: Sports Definitions

(Note: See southpaws as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  (informal, idiomatic) One who is left-handed, especially in sports.
noun:  (baseball) A left-handed pitcher.
noun:  A boxer who leads with the right hand and guards with the left.

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