Usually means: Deliberate act of harming oneself.
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We found 26 dictionaries that define the word self-destruction:

General (24 matching dictionaries)
  1. self-destruction: Merriam-Webster
  2. self-destruction: Oxford Learner's Dictionaries
  3. self-destruction: American Heritage Dictionary of the English Language
  4. self-destruction, self-destruction: Collins English Dictionary
  5. self-destruction: Vocabulary.com
  6. Self-Destruction, Self-destruction, self-destruction: Wordnik
  7. self-destruction: Cambridge Advanced Learner's Dictionary
  8. self-destruction: Wiktionary
  9. self-destruction: Webster's New World College Dictionary, 4th Ed.
  10. self-destruction: The Wordsmyth English Dictionary-Thesaurus
  11. self-destruction: Infoplease Dictionary
  12. self-destruction: Dictionary.com
  13. self-destruction: Cambridge Essential American English Dictionary
  14. Self-destruction: Wikipedia, the Free Encyclopedia
  15. Self-destruction: Online Plain Text English Dictionary
  16. self-destruction: Webster's Revised Unabridged, 1913 Edition
  17. self-destruction: Rhymezone
  18. Self-destruction: AllWords.com Multi-Lingual Dictionary
  19. self-destruction: Webster's 1828 Dictionary
  20. self-destruction: FreeDictionary.org
  21. self-destruction: Mnemonic Dictionary
  22. self-destruction: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. self-destruction: Encyclopedia

Medicine (1 matching dictionary)
  1. self-destruction: Merriam-Webster Medical Dictionary

Definitions from Wiktionary (self-destruction)

noun:  The act of something destroying itself.

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