Usually means: Eliminate possibility through evidence, investigation.
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We found 21 dictionaries that define the word rule out:

General (13 matching dictionaries)
  1. rule out: Longman Dictionary of Contemporary English
  2. rule out: Merriam-Webster
  3. rule out: Collins English Dictionary
  4. rule out: Vocabulary.com
  5. rule-out: Wordnik
  6. rule out: Wiktionary
  7. rule out: Dictionary.com
  8. rule out: Rhymezone
  9. rule out: FreeDictionary.org
  10. rule out: Mnemonic Dictionary
  11. rule out: TheFreeDictionary.com

Business (1 matching dictionary)
  1. rule out: Legal dictionary

Computing (1 matching dictionary)
  1. rule out: Encyclopedia

Medicine (4 matching dictionaries)
  1. Rule out: MedTerms.com Medical Dictionary
  2. Rule out: MedFriendly Glossary
  3. rule-out, rule out: Medical dictionary
  4. Rule out: Drug Medical Dictionary

Miscellaneous (1 matching dictionary)
  1. rule out: Idioms

Tech (1 matching dictionary)
  1. Washington State Definitions and Abbreviations of Vetrinary Terms (No longer online)

(Note: See rule_outs as well.)

Definitions from Wiktionary (rule out)

verb:  (transitive) To cross an item out by drawing a straight line through it, as with a ruler.
verb:  (idiomatic, transitive) To reject an option from a list of possibilities.
verb:  (idiomatic, transitive) To make something impossible.
verb:  (transitive) To disallow.
verb:  (transitive) To make unavailable.

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