Usually means: Disease causing widespread death, suffering.
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We found 48 dictionaries that define the word plague:

General (27 matching dictionaries)
  1. plague: Longman Dictionary of Contemporary English
  2. plague: Merriam-Webster
  3. plague, plague: Oxford Learner's Dictionaries
  4. plague: American Heritage Dictionary of the English Language
  5. plague: Collins English Dictionary
  6. plague: Vocabulary.com
  7. Plague, plague: Wordnik
  8. plague: Cambridge Advanced Learner's Dictionary
  9. plague, the plague: Wiktionary
  10. plague: Webster's New World College Dictionary, 4th Ed.
  11. plague: The Wordsmyth English Dictionary-Thesaurus
  12. plague: Infoplease Dictionary
  13. plague, the plague: Dictionary.com
  14. plague (n.): Online Etymology Dictionary
  15. plague: Cambridge Essential American English Dictionary
  16. Plague (disambiguation), Plague (disease), Plague (painting), Plague (song), Plague, Plague, The Plague (American band), The Plague (Brotha Lynch Hung album), The Plague (English band), The Plague (English punk rock band), The Plague (Father Ted), The Plague (New Zealand band), The Plague (Nuclear Assault EP), The Plague (band), The Plague (magazine), The Plague, The plague: Wikipedia, the Free Encyclopedia
  17. Plague: Online Plain Text English Dictionary
  18. plague: Webster's Revised Unabridged, 1913 Edition
  19. plague: Rhymezone
  20. plague: AllWords.com Multi-Lingual Dictionary
  21. plague: Webster's 1828 Dictionary
  22. plague: FreeDictionary.org
  23. plague: Mnemonic Dictionary
  24. plague: TheFreeDictionary.com
  25. plague: Wikimedia Commons US English Pronunciations

Business (1 matching dictionary)
  1. Plague (disambiguation), plague: Legal dictionary

Computing (1 matching dictionary)
  1. Plague (disambiguation), plague: Encyclopedia

Medicine (12 matching dictionaries)
  1. plague: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. Plague: MedTerms.com Medical Dictionary
  4. Medical Dictionary (No longer online)
  5. Plague: Merck Manuals
  6. online medical dictionary (No longer online)
  7. Specific Diseases/Disorders (No longer online)
  8. Plague: MEDLINE plus Illustrated Medical Encyclopedia
  9. Plague (disambiguation), plague: Medical dictionary
  10. University of Maryland Glossary of Medical Terms (No longer online)
  11. Plague: Drug Medical Dictionary
  12. Hyperdictionary (No longer online)

Miscellaneous (4 matching dictionaries)
  1. Brilliant Dream Dictionary (No longer online)
  2. Plague, Plague, Plague: Terminology and Descriptions of Geneaological Words
  3. Glossary of Terrorism Terms (No longer online)
  4. plague: Idioms

Religion (1 matching dictionary)
  1. Plague: Easton Bible

Science (1 matching dictionary)
  1. Agricultural Thesaurus and Glossary (No longer online)

Slang (1 matching dictionary)
  1. The Plague, plague: Urban Dictionary

(Note: See plagued as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  (often used with the, sometimes capitalized: the Plague) The bubonic plague, the pestilent disease caused by the virulent bacterium Yersinia pestis.
noun:  (pathology) An epidemic or pandemic caused by any pestilence, but specifically by the above disease.
noun:  A widespread affliction, calamity, or destructive influx, especially when seen as divine retribution.
noun:  (figurative) A grave nuisance, whatever greatly irritates.
noun:  (ornithology) A group of common grackles.
verb:  (transitive) To harass, pester or annoy someone persistently or incessantly.
verb:  (transitive) To afflict with a disease or other calamity.

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