Usually means: Single synapse between two neurons.
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We found 11 dictionaries that define the word monosynaptic:

General (7 matching dictionaries)
  1. monosynaptic: Merriam-Webster
  2. monosynaptic: Oxford Learner's Dictionaries
  3. monosynaptic: American Heritage Dictionary of the English Language
  4. monosynaptic: Collins English Dictionary
  5. monosynaptic: Wiktionary
  6. monosynaptic: Dictionary.com
  7. monosynaptic: TheFreeDictionary.com

Medicine (4 matching dictionaries)
  1. monosynaptic: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. online medical dictionary (No longer online)
  4. monosynaptic: Medical dictionary

(Note: See monosynaptically as well.)

Definitions from Wiktionary (monosynaptic)

adjective:  (neuroanatomy) Having, or involving a single synapse
adjective:  (derogatory) Stupid, lacking in brainpower

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