Usually means: Bipolar disorder with mood swings.
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We found 25 dictionaries that define the word manic depressive:

General (21 matching dictionaries)
  1. manic depressive: Longman Dictionary of Contemporary English
  2. manic-depressive: Merriam-Webster
  3. manic-depressive: Oxford Learner's Dictionaries
  4. manic-depressive: American Heritage Dictionary of the English Language
  5. manic-depressive, manic-depressive: Collins English Dictionary
  6. manic-depressive: Vocabulary.com
  7. manic-depressive: Wordnik
  8. manic depressive: Cambridge Advanced Learner's Dictionary
  9. manic-depressive, manic depressive: Wiktionary
  10. manic-depressive: Webster's New World College Dictionary, 4th Ed.
  11. manic-depressive: The Wordsmyth English Dictionary-Thesaurus
  12. manic-depressive: Infoplease Dictionary
  13. manic-depressive, manic depressive: Dictionary.com
  14. manic-depressive: Cambridge Essential American English Dictionary
  15. Manic-depressive, Manic depressive: Wikipedia, the Free Encyclopedia
  16. manic-depressive: Rhymezone
  17. manic-depressive: FreeDictionary.org
  18. manic-depressive: Mnemonic Dictionary
  19. manic-depressive: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. Manic depressive, manic-depressive: Encyclopedia

Medicine (3 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. online medical dictionary (No longer online)
  3. manic-depressive, manic depressive: Medical dictionary

Definitions from Wiktionary (Manic depressive)

noun:  Alternative spelling of manic-depressive [(dated) A person with manic depression.]

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