Usually means: Strong alkaline solution, dissolves organic material.
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We found 37 dictionaries that define the word lye:

General (21 matching dictionaries)
  1. lye: Merriam-Webster
  2. lye: Oxford Learner's Dictionaries
  3. lye: Collins English Dictionary
  4. lye: Vocabulary.com
  5. Lye, lye: Wordnik
  6. lye: Wiktionary
  7. lye: Webster's New World College Dictionary, 4th Ed.
  8. lye: The Wordsmyth English Dictionary-Thesaurus
  9. lye: Infoplease Dictionary
  10. lye: Dictionary.com
  11. lye: Online Etymology Dictionary
  12. Lye (disambiguation), Lye: Wikipedia, the Free Encyclopedia
  13. Lye: Online Plain Text English Dictionary
  14. lye: Webster's Revised Unabridged, 1913 Edition
  15. lye: Rhymezone
  16. Lye: AllWords.com Multi-Lingual Dictionary
  17. lye: Webster's 1828 Dictionary
  18. lye: Stammtisch Beau Fleuve Acronyms
  19. lye: FreeDictionary.org
  20. lye: Mnemonic Dictionary
  21. lye: TheFreeDictionary.com

Art (1 matching dictionary)
  1. Natural Magick (No longer online)

Computing (1 matching dictionary)
  1. lye: Encyclopedia

Medicine (6 matching dictionaries)
  1. lye: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. Medical Dictionary (No longer online)
  4. online medical dictionary (No longer online)
  5. lye: Medical dictionary
  6. University of Maryland Glossary of Medical Terms (No longer online)

Miscellaneous (4 matching dictionaries)
  1. Encyclopedia of Graphic Symbols (No longer online)
  2. Sound-Alike Words (No longer online)
  3. LYE: Acronym Finder
  4. LYE: Three Letter Words with definitions

Slang (2 matching dictionaries)
  1. lye: Green’s Dictionary of Slang
  2. Totally Unofficial Rap (No longer online)

Tech (2 matching dictionaries)
  1. Organic Salon Glossary (No longer online)
  2. Glossary for the Modern Soap Maker (No longer online)

(Note: See lyeing as well.)

Definitions from Wiktionary (lye)

noun:  An alkaline liquid made by leaching ashes (usually wood ashes).
noun:  Potassium or sodium hydroxide (caustic soda).
verb:  To treat with lye.
noun:  (UK, rail transport) A short side line, connected with the main line; a turn-out; a siding.
noun:  (with the) A suburban area in the Metropolitan Borough of Dudley, West Midlands, England (OS grid ref SO9284).
noun:  (rare) A diminutive of the female given name Lyanna.
verb:  Obsolete spelling of lie. [(intransitive) To rest in a horizontal position on a surface.]
noun:  Obsolete spelling of lie. [(golf) The terrain and conditions surrounding the ball before it is struck.]

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