Usually means: Relax, release tension, become flexible.
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We found 17 dictionaries that define the word loosen up:

General (13 matching dictionaries)
  1. loosen up: Longman Dictionary of Contemporary English
  2. loosen up: Merriam-Webster
  3. loosen up: Oxford Learner's Dictionaries
  4. loosen up: Vocabulary.com
  5. loosen (sb) up, loosen (sth) up: Cambridge Advanced Learner's Dictionary
  6. loosen up: Wiktionary
  7. loosen up: Dictionary.com
  8. loosen up: Rhymezone
  9. loosen up: FreeDictionary.org
  10. loosen up: Mnemonic Dictionary
  11. loosen up: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. loosen up: Encyclopedia

Miscellaneous (2 matching dictionaries)
  1. Encyclopedia of Graphic Symbols (No longer online)
  2. loosen up: Idioms

Slang (1 matching dictionary)
  1. loosen up: Urban Dictionary

Definitions from Wiktionary (loosen up)

verb:  (intransitive) To become loose; to loosen; to relax (a muscle, etc.).
verb:  (colloquial) To relax; to act less seriously.

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