Usually means: Joints connecting fingers to hand.
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We found 20 dictionaries that define the word knuckles:

General (13 matching dictionaries)
  1. knuckles: Merriam-Webster
  2. knuckles: Collins English Dictionary
  3. knuckles: Vocabulary.com
  4. Knuckles, knuckles: Wordnik
  5. knuckles: Cambridge Advanced Learner's Dictionary
  6. Knuckles, knuckles: Wiktionary
  7. knuckles: Dictionary.com
  8. knuckles: Cambridge Essential American English Dictionary
  9. Knuckles: Wikipedia, the Free Encyclopedia
  10. knuckles: Rhymezone
  11. knuckles: FreeDictionary.org
  12. knuckles: Mnemonic Dictionary
  13. knuckles: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. knuckles: Encyclopedia

Medicine (2 matching dictionaries)
  1. knuckles: Merriam-Webster Medical Dictionary
  2. knuckles: Medical dictionary

Miscellaneous (2 matching dictionaries)
  1. Brilliant Dream Dictionary (No longer online)
  2. knuckles: Idioms

Slang (1 matching dictionary)
  1. Knuckles: Urban Dictionary

Tech (1 matching dictionary)
  1. National Weather Service Glossary (No longer online)

(Note: See knuckle as well.)

Definitions from Wiktionary (Knuckles)

noun:  (US, archaic) A nickname for a man employed for his fistfighting skill.

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