Usually means: Surgical alteration of the brain.
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We found 12 dictionaries that define the word frontal lobotomy:

General (9 matching dictionaries)
  1. frontal lobotomy: Oxford Learner's Dictionaries
  2. frontal lobotomy: American Heritage Dictionary of the English Language
  3. frontal lobotomy: Vocabulary.com
  4. frontal lobotomy: Cambridge Advanced Learner's Dictionary
  5. frontal lobotomy: Dictionary.com
  6. frontal lobotomy: Rhymezone
  7. frontal lobotomy: FreeDictionary.org
  8. frontal lobotomy: Mnemonic Dictionary
  9. frontal lobotomy: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. frontal lobotomy: Encyclopedia

Medicine (2 matching dictionaries)
  1. frontal lobotomy: Merriam-Webster Medical Dictionary
  2. frontal lobotomy: Medical dictionary

Definitions from WordNet (frontal lobotomy)

noun:  surgical interruption of nerve tracts to and from the frontal lobe of the brain; often results in marked cognitive and personality changes

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