Usually means: Initial injury or kill scored.
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We found 8 dictionaries that define the word first blood:

General (6 matching dictionaries)
  1. first blood: Merriam-Webster
  2. first blood, first blood: Oxford Learner's Dictionaries
  3. first blood: Collins English Dictionary
  4. first blood: Wiktionary
  5. First Blood (Supernatural), First Blood (Wentworth), First Blood (band), First Blood (disambiguation), First Blood (film), First Blood (novel), First Blood (short story), First Blood, First blood: Wikipedia, the Free Encyclopedia
  6. first blood: TheFreeDictionary.com

Slang (1 matching dictionary)
  1. first blood: Urban Dictionary

Sports (1 matching dictionary)
  1. Mountain Bike Slang (No longer online)

Definitions from Wiktionary (first blood)

noun:  The condition in a duel in which the first one to draw blood from the other wins.
noun:  The first damage or reverse inflicted on an opponent in a conflict.
noun:  (sports) The first score in a competition.

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