Usually means: Rodent species native to Americas.
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We found 13 dictionaries that define the word cotton rat:

General (11 matching dictionaries)
  1. cotton rat: Merriam-Webster
  2. cotton rat: Oxford Learner's Dictionaries
  3. cotton rat: Vocabulary.com
  4. cotton rat: Wordnik
  5. cotton rat: Wiktionary
  6. Cotton rat, cotton rat: Dictionary.com
  7. Cotton rat: Wikipedia, the Free Encyclopedia
  8. cotton rat: Rhymezone
  9. cotton rat: FreeDictionary.org
  10. cotton rat: Mnemonic Dictionary
  11. cotton rat: TheFreeDictionary.com

Medicine (2 matching dictionaries)
  1. Cotton rat, Rat, cotton: MedTerms.com Medical Dictionary
  2. Cotton rat, Rat, cotton: Drug Medical Dictionary

(Note: See cotton_rats as well.)

Definitions from Wiktionary (cotton rat)

noun:  Any member of the rodent genus Sigmodon, that build their nests from cotton, and can damage cotton crops, found from the southwestern US to Surinam, Brazil, and Peru.

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