Definitions from Wiktionary (breakthrough)

▸ adjective:  Characterized by major progress or overcoming some obstacle.
▸ adjective:  (immunology) Involving the contraction of a disease by a person with a decreased susceptibility, such as a person who has been vaccinated to help prevent that disease.
▸ noun:  (military) An advance through and past enemy lines.
▸ noun:  Any major progress; such as a great innovation or discovery that overcomes a significant obstacle.
▸ noun:  (sports) The penetration of the opposition's defence.
▸ noun:  (construction) The penetration of a separating wall or the remaining distance to an adjacent hollow (a crosscut in mining) or between two parts of a tunnel build from both ends; knockthrough.
▸ noun:  (medicine, sometimes attributive) The emergence or one or more symptoms of a condition despite medication or other medical treatment.
▸ Also see breakthrough

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