Usually means: Over-the-counter cold and flu medicine.
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We found 5 dictionaries that define the word NyQuil:

General (3 matching dictionaries)
  1. nyquil: Longman Dictionary of Contemporary English
  2. Nyquil, nyquil: Wordnik
  3. NyQuil, Nyquil: Wikipedia, the Free Encyclopedia

Slang (2 matching dictionaries)
  1. Totally Unofficial Rap (No longer online)

Definitions from Wikipedia (NyQuil)

noun:  Vicks NyQuil is a brand of over-the-counter medication manufactured by Procter & Gamble intended for the relief of various symptoms of the common cold; the spokesman is Michael Daingerfield of CBS, Global and Nickelodeon fame.

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