Usually means: Device causing large-scale devastation.
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We found 13 dictionaries that define the word weapon of mass destruction:

General (10 matching dictionaries)
  1. weapon of mass destruction: Merriam-Webster
  2. weapon of mass destruction: Oxford Learner's Dictionaries
  3. weapon of mass destruction: Vocabulary.com
  4. weapon of mass destruction: Wiktionary
  5. weapon of mass destruction: Dictionary.com
  6. Weapon of mass destruction: Wikipedia, the Free Encyclopedia
  7. weapon of mass destruction: Rhymezone
  8. weapon of mass destruction: FreeDictionary.org
  9. weapon of mass destruction: Mnemonic Dictionary
  10. weapon of mass destruction: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. weapon of mass destruction: Encyclopedia

Medicine (1 matching dictionary)
  1. weapon of mass destruction: Medical dictionary

Slang (1 matching dictionary)
  1. weapon of mass destruction: Urban Dictionary

Definitions from Wiktionary (weapon of mass destruction)

noun:  Any human-made weapon causing indiscriminate large-scale death or destruction, especially a biological weapon, chemical weapon, nuclear weapon or radiological weapon.

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