Usually means: Operational and fully functioning smoothly.
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We found 9 dictionaries that define the word up and running:

General (7 matching dictionaries)
  1. up and running: Longman Dictionary of Contemporary English
  2. up and running: Oxford Learner's Dictionaries
  3. up and running: Collins English Dictionary
  4. up and running: Cambridge Advanced Learner's Dictionary
  5. up and running: Wiktionary

Miscellaneous (1 matching dictionary)
  1. up and running: Idioms

Slang (1 matching dictionary)
  1. up and running: Urban Dictionary

Definitions from Wiktionary (up and running)

adjective:  (idiomatic) operational, in operation

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