Usually means: Person excessively using methamphetamine or stimulants.
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We found 10 dictionaries that define the word tweaker:

General (7 matching dictionaries)
  1. tweaker: Merriam-Webster
  2. tweaker: Collins English Dictionary
  3. Tweaker, tweaker: Wordnik
  4. tweaker: Wiktionary
  5. tweaker: Dictionary.com
  6. Tweaker (Chris Vrenna), Tweaker (band), Tweaker (build tool), Tweaker (disambiguation), Tweaker: Wikipedia, the Free Encyclopedia
  7. tweaker: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. Tweaker: Encyclopedia

Slang (2 matching dictionaries)
  1. tweaker, tweaker: Green’s Dictionary of Slang
  2. Tweaker: Street Terms: Drugs and the Drug Trade

Definitions from Wiktionary (tweaker)

noun:  A person who tweaks something.
noun:  A tool, especially a screwdriver, for making small adjustments.
noun:  (slang) A person addicted to methamphetamine.
noun:  (cricket, slang) A spin bowler.

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