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We found 2 dictionaries that define the word tie oneself in knots:

General (2 matching dictionaries)
  1. tie oneself (up) in knots, tie oneself in knots: Merriam-Webster
  2. tie oneself in knots: Wiktionary

Definitions from Wiktionary (tie oneself in knots)

verb:  (idiomatic) To put oneself in a difficult situation.
verb:  (idiomatic) To become anxious or upset; to fret.

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