Usually means: Allow natural progression without interference.
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We found 7 dictionaries that define the word take its course:

General (3 matching dictionaries)
  1. take its course: Collins English Dictionary
  2. take its course: TheFreeDictionary.com
  3. take its course: Wiktionary

Business (1 matching dictionary)
  1. take its course: Legal dictionary

Computing (1 matching dictionary)
  1. take its course: Encyclopedia

Medicine (1 matching dictionary)
  1. take its course: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. take its course: Idioms

Definitions from Wiktionary (take its course)

verb:  To progress in a natural manner without interference.

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