Might mean (unverified): Attempt or try something challenging.
Definitions Related words Mentions
We found 2 dictionaries that define the word take a run at:

General (2 matching dictionaries)
  1. take a run at: Merriam-Webster
  2. take a run at: Wiktionary

Definitions from Wiktionary (take a run at)

verb:  (transitive, idiomatic) To attempt to achieve or acquire.
verb:  (transitive, idiomatic) To attack or challenge or to try to attack or challenge.

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