Usually means: Exert extreme effort or anxiety.
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We found 13 dictionaries that define the word sweat blood:

General (10 matching dictionaries)
  1. sweat blood: Longman Dictionary of Contemporary English
  2. sweat blood: Merriam-Webster
  3. sweat blood: Oxford Learner's Dictionaries
  4. sweat blood: Collins English Dictionary
  5. sweat blood: Cambridge Advanced Learner's Dictionary
  6. sweat blood: Wiktionary
  7. sweat blood: Dictionary.com
  8. sweat blood: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. sweat blood: Encyclopedia

Medicine (1 matching dictionary)
  1. sweat blood: Medical dictionary

Miscellaneous (1 matching dictionary)
  1. sweat blood: Idioms

Definitions from Wiktionary (sweat blood)

verb:  (informal) To work very hard.
verb:  (informal) To be extremely anxious.

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