Usually means: Replacement of atom or group.
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We found 9 dictionaries that define the word substitution reaction:

General (5 matching dictionaries)
  1. substitution reaction: Wiktionary
  2. substitution reaction: Infoplease Dictionary
  3. substitution reaction: Dictionary.com
  4. Substitution reaction: Wikipedia, the Free Encyclopedia
  5. substitution reaction: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. substitution reaction: Encyclopedia

Medicine (1 matching dictionary)
  1. General Glossary (No longer online)

Science (2 matching dictionaries)
  1. Chemistry Dictionary (No longer online)
  2. substitution reaction: PHYSICAL ORGANIC CHEMISTRY

Definitions from Wiktionary (substitution reaction)

noun:  (chemistry) a reaction in which one functional group is replaced with another

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