Usually means: Full of spite or malice.
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We found 18 dictionaries that define the word spleenful:

General (15 matching dictionaries)
  1. spleenful: Merriam-Webster
  2. spleenful: Oxford Learner's Dictionaries
  3. spleenful: American Heritage Dictionary of the English Language
  4. spleenful: Collins English Dictionary
  5. spleenful: Wordnik
  6. spleenful: Wiktionary
  7. spleenful: Webster's New World College Dictionary, 4th Ed.
  8. spleenful: Infoplease Dictionary
  9. spleenful: Dictionary.com
  10. Spleenful: Online Plain Text English Dictionary
  11. spleenful: Webster's Revised Unabridged, 1913 Edition
  12. Spleenful: AllWords.com Multi-Lingual Dictionary
  13. spleenful: Webster's 1828 Dictionary
  14. spleenful: FreeDictionary.org
  15. spleenful: TheFreeDictionary.com

Business (1 matching dictionary)
  1. spleenful: Legal dictionary

Computing (1 matching dictionary)
  1. spleenful: Encyclopedia

Medicine (1 matching dictionary)
  1. spleenful: Medical dictionary

Definitions from Wiktionary (spleenful)

adjective:  Full of spleen; spiteful.
noun:  A quantity of invective.
noun:  More than one can take.

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