Might mean (unverified): Make more effeminate or weaker.
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We found 2 dictionaries that define the word sissify:

General (1 matching dictionary)
  1. sissify: Wiktionary

Slang (1 matching dictionary)
  1. sissify: Urban Dictionary

Definitions from Wiktionary (sissify)

verb:  (transitive) To make sissy; to emasculate.

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