Usually means: Exhausted and frustrated with situation.
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We found 5 dictionaries that define the word sick and tired:

General (5 matching dictionaries)
  1. sick and tired: Merriam-Webster
  2. sick and tired: Wiktionary
  3. sick and tired: Dictionary.com
  4. Sick and Tired (Anastacia song), Sick and Tired (Chris Kenner song), Sick and Tired (The Cardigans song): Wikipedia, the Free Encyclopedia
  5. sick and tired: TheFreeDictionary.com

Definitions from Wiktionary (sick and tired)

adjective:  (idiomatic) Bored to the point of weariness.
adjective:  (idiomatic) Annoyed or frustrated with something or someone, to the point of losing one's temper or patience.
adjective:  Used other than figuratively or idiomatically: see sick, tired.

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