Usually means: Mistake due to poor judgment.
Definitions Related words Mentions
We found 11 dictionaries that define the word screw-up:

General (8 matching dictionaries)
  1. screw-up, screw-up: Collins English Dictionary
  2. Screw-Up, Screw-up, screw-up: Wordnik
  3. screw-up: Wiktionary
  4. screw-up: Webster's New World College Dictionary, 4th Ed.
  5. screw-up: Dictionary.com
  6. screw-up: TheFreeDictionary.com

Slang (3 matching dictionaries)
  1. screw-up: Green’s Dictionary of Slang
  2. screw-up: ESL Slang page
  3. Screw-Up: Urban Dictionary

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  Alternative spelling of screwup [(colloquial) A substantial mistake, usually causing problems for more people than just the person or group who made it.]

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