Usually means: Mentally unstable or irrational behavior.
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We found 11 dictionaries that define the word screw loose:

General (9 matching dictionaries)
  1. screw-loose: Vocabulary.com
  2. screw-loose: Dictionary.com
  3. Screw Loose: Wikipedia, the Free Encyclopedia
  4. screw-loose: Rhymezone
  5. Screw Loose: Dictionary of Phrase and Fable (1898)
  6. screw-loose: FreeDictionary.org
  7. screw-loose: Mnemonic Dictionary
  8. screw-loose: TheFreeDictionary.com
  9. screw loose: Wiktionary

Slang (2 matching dictionaries)
  1. screw loose: English slang and colloquialisms used in the United Kingdom
  2. screw loose: Urban Dictionary

Definitions from Wiktionary (screw loose)

noun:  (slang) A state of insanity or eccentricity.
noun:  (slang, archaic) A state of enmity or disagreement.

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