Usually means: Persistent wound that continuously discharges.
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We found 5 dictionaries that define the word running sore:

General (5 matching dictionaries)
  1. running sore: Longman Dictionary of Contemporary English
  2. running sore: Cambridge Advanced Learner's Dictionary
  3. running sore: Wiktionary

Definitions from Wiktionary (running sore)

noun:  Used other than figuratively or idiomatically: see running, sore.; an ulcer that oozes pus.
noun:  A festering problem; a situation that remains problematic or gets worse over time.

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