Definitions from Wiktionary (run mad)
▸ verb: (now rare) To go mad.
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▸ verb: (now rare) To go mad.
Similar:
go mad,
go crazy,
go bonkers,
run amok,
go nuts,
lose one's mind,
go mental,
run wild,
lose it,
take leave of one's senses,
more...
Opposite:
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▸ Invented words related to run mad