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We found 3 dictionaries that define the word prime directive:

General (2 matching dictionaries)
  1. prime directive: Wiktionary
  2. Prime Directive (Star Trek novel), Prime Directive (album), Prime Directive (disambiguation), Prime Directive (role-playing game), Prime Directive: Wikipedia, the Free Encyclopedia

Slang (1 matching dictionary)
  1. Prime Directive: Urban Dictionary

Definitions from Wiktionary (prime directive)

noun:  An order or mission which presents the overriding control over a course of action.

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