Usually means: Toxic substance causing sharp irritation.
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We found 6 dictionaries that define the word prickly poison:

General (3 matching dictionaries)
  1. prickly poison: Merriam-Webster
  2. prickly poison: TheFreeDictionary.com
  3. prickly poison: Wiktionary

Business (1 matching dictionary)
  1. prickly poison: Legal dictionary

Computing (1 matching dictionary)
  1. prickly poison: Encyclopedia

Medicine (1 matching dictionary)
  1. prickly poison: Medical dictionary

Definitions from Wiktionary (prickly poison)

noun:  The plant Gastrolobium spinosum.

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