Usually means: Changes preceding development of cancer.
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We found 5 dictionaries that define the word preneoplastic:

General (2 matching dictionaries)
  1. preneoplastic: Wiktionary
  2. preneoplastic: Dictionary.com

Medicine (3 matching dictionaries)
  1. preneoplastic: Merriam-Webster Medical Dictionary
  2. online medical dictionary (No longer online)
  3. preneoplastic: Medical dictionary

Definitions from Wiktionary (preneoplastic)

adjective:  Before the formation of a neoplasm (tumor); meant usually with a notion of a suspected or putative chain of causation, as opposed to random chance alone.

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