Usually means: Surgical severing of brain connections.
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We found 10 dictionaries that define the word prefrontal leucotomy:

General (8 matching dictionaries)
  1. prefrontal leucotomy: Collins English Dictionary
  2. prefrontal leucotomy: Vocabulary.com
  3. prefrontal leucotomy: Dictionary.com
  4. Prefrontal leucotomy: Wikipedia, the Free Encyclopedia
  5. prefrontal leucotomy: Rhymezone
  6. prefrontal leucotomy: FreeDictionary.org
  7. prefrontal leucotomy: Mnemonic Dictionary
  8. prefrontal leucotomy: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. prefrontal leucotomy: Encyclopedia

Medicine (1 matching dictionary)
  1. prefrontal leucotomy: Medical dictionary

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Definitions from WordNet (prefrontal leucotomy)

▸ noun:  surgical interruption of nerve tracts to and from the frontal lobe of the brain; often results in marked cognitive and personality changes


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