Usually means: Difficulty breathing in upright position.
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We found 5 dictionaries that define the word platypnea:

General (3 matching dictionaries)
  1. platypnea: Wiktionary
  2. platypnea: Dictionary.com
  3. Platypnea: Wikipedia, the Free Encyclopedia

Medicine (2 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. Platypnea: Medical dictionary

Definitions from Wiktionary (platypnea)

noun:  (medicine) Shortness of breath that occurs when the patient is upright, that is, sufficient breathing only when lying flat.

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